dr. Sorin ISTRAIL
Professor of Computer Science
Center for Computational Molecular Biology and Computer Science
Department, Brown University
Providence
S.U.A.
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Computational Biology: From Genomics to Protein Folding and
to Systems Biology
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ABSTRACT
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With the recent availability of tools for genome assembly, assembly
comparison, and automatic annotation of genomes, genomics entered
its /post-genome sequence/ phase devoted to understanding the
control systems of the cell. Building on its success in bio-molecular
sequence analysis, comparative genomics is continually expanding
its scope and methods by striving to better understand the components
of the cell.  In this talk, I will present an overview of our
work in assembly comparison, protein folding, genetic variation,
immunology, and genomic regulatory systems.  The comparative
genomics of the geometries of protein folds, patterns of inheritance
of complex disease, immunopeptidomes, and logics of regulatory
networks, provide pathways that will lead toward the acquisition
of scientific control over major life processes.
          
SHORT CV
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Dr.Sorin Istrail has been Senior Director, Head of the Informatics
Research Department at Celera Genomics/Applied Biosystems, Rockville,
MD, USA since april 2000.
His research focuses on computational biology (systems biology,
protein folding, SNPs and haplotypes analysis and comparative
genomics), computer science and statistical physics.
Before joining Celera Genomics dr.Istrail held several research
and teaching positions at Sandia National Laboratories (Albuquerque,
NM, USA), California Institute of Technology (Pasadena, CA,
USA),
George Washington University (Washington, DC, USA), University
of New Mexico (Albuquerque, NM, USA), Wesleyan University (Middletown,
CT, USA), Massachusetts Institute of Technology (Cambridge,
MA, USA), and University Al. I. Cuza (Iasi, Romania).
Dr.Istrail completed his PhD in Computer Science in 1979 at
the University of Bucharest (Bucharest, Romania) and his BSc
in Computer Science in 1975 at the Al. I. Cuza University (Iasi,
Romania).